Quantitative Nasal Cultures from Carriers of Staphylococcus aureus: Effects of Oral Therapy with Erythromycin, Rosamicin, and Placebo
AUTOR(ES)
Wilson, Samuel Z.
RESUMO
Serial quantitative nasal cultures were performed on 87 healthy nasal carriers of Staphylococcus aureus, who were randomly assigned to 7 days of oral therapy with erythromycin, rosamicin (an investigational macrolide antibiotic), or placebo. Staphylococcal carrier rates decreased during therapy with both antibiotics; however, erythromycin was significantly more effective in lowering carrier rates than was rosamicin. The anti-staphylococcal effects of both antibiotics were similar when the mean numbers of S. aureus isolated from positive cultures during therapy were compared. Side effects to each regimen were minimal.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352669Documentos Relacionados
- In Vivo Effects of Josamycin, Erythromycin, and Placebo Therapy on Nasal Carriage of Staphylococcus aureus
- In Vitro Activity of Rosamicin, Josamycin, Erythromycin, and Clindamycin Against β-Lactamase-Negative and β-Lactamase-Positive Strains of Neisseria gonorrhoeae
- Erythromycin-Inducible Resistance in Staphylococcus aureus: Requirements for Induction
- In Vitro Activity of Josamycin and Rosamicin Against Bacteroides fragilis Compared with Clindamycin, Erythromycin, and Metronidazole
- Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks.
