Quimicas de bacterias : biossintese e atividade biologica de metabolitos da Chromabacterium violaceum brasiliensis
AUTOR(ES)
Raul Alberto Riveros Gonzalez
DATA DE PUBLICAÇÃO
1990
RESUMO
The bacterium Chromobacterium vilaceum which yields 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3-ylidene]-1,3- dihydro-2H-indol-2-one (compound 1) was studied. A study of the biosynthetic capacity in the production of components with biological interest between native strain (BB -78), uncoloured strain and apparently mutant. strain obtained by irradiation of the native strain with light UV was realized. The biosynthetic production of compound 1 was increased by inducing cellular growth with synthetic carboxamides and bio-synthesized metabolites both in the native strain, as well as the irradiated strain. These studies as with the incorporation of IAA C-2 the biogenesis of the compound 1 is propased. Preliminary results of the biological activity of the bromo, acetyl sodium salts and methylol derivatives of compound 1 have shown that they are antitrypanosomal, with the latter having the largest. activity In the toxicity and cytotoxicity studies of these derivatives a similar value of nifurtimox and methylol (at, 450 mM) which to inhibit.s 50% of the synthese the DNA (D50 ) has been found.From the native strain catabolic products of the tryptophane pyrrol-2-carboxylic acid and a compound identified as 5-hydroxy-2-methyl -3-carboetoxy berzofurane were obtained. From irradiated strain p-aminophenol, antranylic acid and isatine were isolated. AlI isolated compound were purified by PLC and identified by UV, IR and NMRH spectroscopies and Mass spectrometry.
ASSUNTO(S)
chromobacterium violaceum bacteriologia
ACESSO AO ARTIGO
http://libdigi.unicamp.br/document/?code=vtls000045405Documentos Relacionados
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