Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.
AUTOR(ES)
Yoshida, H
RESUMO
Thirteen spontaneous quinolone-resistant gyrB mutants of Escherichia coli KL16, including two that were examined previously, were divided into two types according to their quinolone resistance patterns. Type 1 mutants were resistant to all the quinolones tested, while type 2 mutants were resistant to acidic quinolones and were hypersusceptible to amphoteric quinolones. Nucleotide sequence analysis disclosed that all nine type 1 mutants had a point mutation from aspartic acid to asparagine at amino acid 426 and that all four type 2 mutants had a point mutation from lysine to glutamic acid at amino acid 447.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=245234Documentos Relacionados
- Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
- Mutation in the DNA Gyrase A Gene of Escherichia coli That Expands the Quinolone Resistance-Determining Region
- Prevalence of Mutations within the Quinolone Resistance-Determining Region of gyrA, gyrB, parC, and parE and Association with Antibiotic Resistance in Quinolone-Resistant Salmonella enterica
- Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus.
- gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli.
