Radioimmunoassay for Human Alpha1-Fetoprotein

AUTOR(ES)

Silver, Hulbert K. B.

RESUMO

A method of radioimmunoassay has been developed for the quantitation of alpha1-fetoprotein in human serum. The assay requires 20 μl of serum, can be completed in 8 hr, and can reproducibly detect concentrations of 20 ng of alpha1-fetoprotein per ml of serum. Hence, the method is about 500-fold more sensitive for the detection of alpha1-fetoprotein than the Ouchterlony teohnique currently in general use. The procedure is of potential clinical value as an aid in the diagnosis of cancer and a number of noncancerous hepatic diseases.

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