raf/myc-infected erythroid cells are restricted in their ability to terminally differentiate.
AUTOR(ES)
Klinken, S P
RESUMO
A comparison was made of the in vitro erythroid colony-forming abilities of v-raf-, v-myc-, and v-raf/v-myc-containing retroviruses. In methylcellulose, v-raf efficiently produced colonies of well-differentiated hemoglobin-synthesizing erythroid cells, whereas v-raf/v-myc-infected erythroid cells were inhibited from terminally differentiating but retained the ability to replicate extensively. In contrast, v-myc was unable to stimulate the formation of erythroid colonies.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=247858Documentos Relacionados
- Transfection of mouse erythroleukemia cells with myc sequences changes the rate of induced commitment to differentiate.
- In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin.
- Hemin-independent control of globin synthesis in Friend erythroleukemia cells induced to differentiate.
- Monocytes promote tumor cell survival in T-cell lymphoproliferative disorders and are impaired in their ability to differentiate into mature dendritic cells
- An antisense RNA involved in p53 mRNA maturation in murine erythroleukemia cells induced to differentiate.