Reassortment In Vivo: Driving Force for Diversity of Human Rotavirus Strains Isolated in the United Kingdom between 1995 and 1999

AUTOR(ES)

Iturriza-Gómara, Miren

FONTE

American Society for Microbiology

RESUMO

The G and P genotypes of 3,601 rotavirus strains collected in the United Kingdom between 1995 and 1999 were determined (M. Iturriza-Gómara et al., J. Clin. Microbiol. 38:4394–4401, 2000). In 95.4% of the strains the most common G and P combinations, G1P[8], G2P[4], G3P[8], and G4P[8], were found. A small but significant number (2%) of isolates from the remaining strains were reassortants of the most common cocirculating strains, e.g., G1P[4] and G2P[8]. Rotavirus G9P[6] and G9P[8] strains, which constituted 2.7% of all viruses, were genetically closely related in their G components, but the P components of the G9P[8] strains were very closely related to those of cocirculating strains of the more common G types (G1, G3, and G4). In conclusion, genetic interaction by reassortment among cocirculating rotaviruses is not a rare event and contributes significantly to their overall diversity.

Documentos Relacionados

• Molecular Epidemiology of Human Group A Rotavirus Infections in the United Kingdom between 1995 and 1998
• Evidence of High-Frequency Genomic Reassortment of Group A Rotavirus Strains in Bangladesh: Emergence of Type G9 in 1995
• Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo.
• A survey of infections in United Kingdom laboratories, 1994-1995.
• Advice on driving after groin hernia surgery in the United Kingdom: questionnaire survey