Recombinant Staphylococcus aureus Exfoliative Toxins Are Not Bacterial Superantigens
AUTOR(ES)
Plano, Lisa R. W.
FONTE
American Society for Microbiology
RESUMO
Staphylococcal scalded-skin syndrome is an exfoliative dermatitis characterized by the separation of the epidermis at the stratum granulosum. This disruption is mediated by one of two Staphylococcus aureus exotoxins, exfoliative toxins A and B (ETA and ETB). Both ETA and ETB have been reported to be bacterial superantigens. A controversy exists, however, as other data indicate that these exotoxins are not superantigens. Here we demonstrate that recombinant exfoliative toxins produced in Escherichia coli do not act as T-cell mitogens and thus are not bacterial superantigens. These data fit the clinical profile of the disease, which is not associated with the classic symptoms of a superantigen-mediated syndrome.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=97528Documentos Relacionados
- Prevalence of Genes Encoding Pyrogenic Toxin Superantigens and Exfoliative Toxins among Strains of Staphylococcus aureus Isolated from Blood and Nasal Specimens
- Possible receptor for exfoliative toxins produced by Staphylococcus hyicus and Staphylococcus aureus.
- Enzyme-linked immunosorbent assays for Staphylococcus aureus exfoliative toxins A and B and some applications.
- Nonenteric toxins of Staphylococcus aureus.
- Nonenteric Toxins of Staphylococcus aureus