Recombinant Tula hantavirus shows reduced fitness but is able to survive in the presence of a parental virus: analysis of consecutive passages in a cell culture
AUTOR(ES)
Plyusnina, Angelina
FONTE
BioMed Central
RESUMO
Tula hantavirus carrying recombinant S RNA segment (recTULV) grew in a cell culture to the same titers as the original cell adapted variant but presented no real match to the parental virus. Our data showed that the lower competitiveness of recTULV could not be increased by pre-passaging in the cell culture. Nevertheless, the recombinant virus was able to survive in the presence of the parental virus during five consecutive passages. The observed survival time seems to be sufficient for transmission of newly formed recombinant hantaviruses in nature.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=552329Documentos Relacionados
- Tula virus: a newly detected hantavirus carried by European common voles.
- Recombination in Tula Hantavirus Evolution: Analysis of Genetic Lineages from Slovakia
- Transfection-mediated generation of functionally competent Tula hantavirus with recombinant S RNA segment
- Quasispecies in wild-type tula hantavirus populations.
- Mapping of the Regions Involved in Homotypic Interactions of Tula Hantavirus N Protein