Recovery from T cell depletion during murine listeriosis and effect on a T-dependent antibody response.
AUTOR(ES)
Chan, Y Y
RESUMO
During the infection of mice with Listeria monocytogenes, there is a profound depletion of T (Thy-1+ Ig-) lymphocytes between days 1 and 4, followed by an increase in T cells to three times normal levels by day 9. The recovery of T cell numbers required cell proliferation, being sensitive to vinblastin and cyclophosphamide. Adult thymectomy 6 months before infection had no effect on recovery. The repopulating cells were no more sensitive than normal T cells to hydrocortisone. B lymphocytes (Ig+ cells) and null (Thy-1-Ig-) cells increased from day 1 after the injection of either live or (in contrast to T cells) killed Listeria organisms. Their increase was inhibited by vinblastin and cyclophosphamide. Despite T cell depletion, no depression of the antibody response to the T-dependent antigen, sheep erythrocytes, occurred during infection or when spleen cells were adoptively transferred from infected mice to irradiated recipients.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=347794Documentos Relacionados
- Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.
- Elongation Factor T-Dependent Hydrolysis of Guanosine Triphosphate Resistant to Thiostrepton
- Weight reduction of thymus and depletion of lymphocytes of T-dependent areas in peripheral lymphoid tissues of mice infected with Francisella tularensis.
- Modulation of immune response by killed Brucella abortus organisms: comparison of the effects of smooth and rough strains on T-dependent responses.
- Mechanism of lipopolysaccharide-induced immunosuppression: immunological activity of B cell subsets responding to T-dependent or T-independent antigens in lipopolysaccharide-preinjected mice.