Reelin controls position of autonomic neurons in the spinal cord
AUTOR(ES)
Yip, Joseph W.
FONTE
The National Academy of Sciences
RESUMO
Mutation of the reeler gene (Reln) disrupts neuronal migration in several brain regions and gives rise to functional deficits such as ataxic gait and trembling in the reeler mutant mouse. Thus, the Reln product, reelin, is thought to control cell–cell interactions critical for cell positioning in the brain. Although an abundance of reelin transcript is found in the embryonic spinal cord [Ikeda, Y. & Terashima, T. (1997) Dev. Dyn. 210, 157–172; Schiffmann, S. N., Bernier, B. & Goffinet, A. M. (1997) Eur. J. Neurosci. 9, 1055–1071], it is generally thought that neuronal migration in the spinal cord is not affected by reelin. Here, however, we show that migration of sympathetic preganglionic neurons in the spinal cord is affected by reelin. This study thus indicates that reelin affects neuronal migration outside of the brain. Moreover, the relationship between reelin and migrating preganglionic neurons suggests that reelin acts as a barrier to neuronal migration.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=26996Documentos Relacionados
- Assessment of autonomic dysreflexia in patients with spinal cord injury.
- Effect of spinal cord hemisection on rubrospinal neurons in the albino rat.
- Nicotinic actions on neurones of the central autonomic area in rat spinal cord slices.
- Changes in corticospinal facilitation of lower limb spinal motor neurons after spinal cord lesions.
- Microenvironment of respiratory neurons in the in vitro brainstem-spinal cord of neonatal rats.
