Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.
AUTOR(ES)
Lewis, E J
RESUMO
The addition of epidermal growth factor (EGF) to cultures of the rat PCG2 pheochromocytoma cell line increased the level of RNA coding for tyrosine hydroxylase (TH). A region of DNA containing 5'-flanking sequences of the TH gene was fused to a heterologous gene and transfected into a rat anterior pituitary cell line, GH4. The TH gene sequences from +27 to -272 contained information sufficient for the induction of TH by EGF. Two regions within this TH DNA were extensively homologous to the EGF regulatory element of the rat prolactin gene.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=367973Documentos Relacionados
- Insulin-like growth factor I gene expression in isolated rat renal collecting duct is stimulated by epidermal growth factor.
- Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor.
- c-ras-Ha gene expression is regulated by insulin or insulinlike growth factor and by epidermal growth factor in murine fibroblasts.
- Inhibitory effects of interferon on the expression of genes regulated by platelet-derived growth factor.
- Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation.