Regulation of allantoate transport in wild-type and mutant strains of Saccharomyces cerevisiae.
AUTOR(ES)
Chisholm, V T
RESUMO
Accumulation of intracellular allantoin and allantoate is mediated by two distinct active transport systems in Saccharomyces cerevisiae. Allantoin transport (DAL4 gene) is inducible, while allantoate uptake is constitutive (it occurs at full levels in the absence of any allantoate-related compounds from the culture medium). Both systems appear to be sensitive to nitrogen catabolite repression, feedback inhibition, and trans-inhibition. Mutants (dal5) that lack allantoate transport have been isolated. These strains also exhibit a 60% loss of allantoin transport capability. Conversely, dal4 mutants previously described are unable to transport allantoin and exhibit a 50% loss of allantoate transport. We interpret the pleiotropic behavior of the dal4 and dal5 mutations as deriving from a functional interaction between elements of the two transport systems.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=212000Documentos Relacionados
- Binding of cycloheximide to ribosomes from wild-type and mutant strains of Saccharomyces cerevisiae.
- Characterization of TPI gene expression in isogeneic wild-type and gcr1-deletion mutant strains of Saccharomyces cerevisiae.
- Binding of Cycloheximide to Ribosomes from Wild-Type and Mutant Strains of Saccharomyces cerevisiae
- Glutamate Transport in Wild-Type and Mutant Strains of Escherichia coli
- Cystathionine Metabolism in Methionine Auxotrophic and Wild-Type Strains of Saccharomyces cerevisiae
