Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10

AUTOR(ES)

Riederer, Beat M.

FONTE

The National Academy of Sciences of the USA

RESUMO

Dynamic assembly and disassembly of microtubules is essential for cell division, cell movements, and intracellular transport. In the developing nervous system, microtubule dynamics play a fundamental role during neurite outgrowth, elongation, and branching, but the molecular mechanisms involved are unknown. SCG10 is a neuron-specific protein that is membrane-associated and highly enriched in growth cones. Here we show that SCG10 binds to microtubules, inhibits their assembly, and can induce microtubule disassembly. We also show that SCG10 overexpression enhances neurite outgrowth in a stably transfected neuronal cell line. These data identify SCG10 as a key regulator of neurite extension through regulation of microtubule instability.

Documentos Relacionados

• NFAT-3 Is a Transcriptional Repressor of the Growth-associated Protein 43 during Neuronal Maturation*
• The 43-kDa neuronal growth-associated protein (GAP-43) is present in plasma membranes of rat astrocytes.
• Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia
• Growth-associated protein GAP-43 is expressed selectively in associative regions of the adult human brain.
• Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts.