Regulation of Protein Synthesis in HeLa Cells: III. Inhibition During Poliovirus Infection
AUTOR(ES)
Leibowitz, R.
RESUMO
The mechanism of inhibition of host cell protein synthesis by poliovirus has been studied by examining the behavior of host polyribosomes and polyribosome-associated messenger ribonucleic acid (mRNA). Virus infection appears to result in a specific inhibition of the initiation of translation of host cell mRNA. The site of inhibition does not appear to be mRNA itself. Human cells respond to virus infection by producing a factor antagonistic to the virus inhibition which promotes the initiation of host mRNA translation. The production of the host factor is sensitive to actinomycin; however, the behavior of the host cell factor and that of host mRNA appear distinctly different.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=376244Documentos Relacionados
- Programming of Poliovirus Inhibition of Deoxyribonucleic Acid Synthesis in HeLa Cells
- Inhibition of Protein Synthesis in Intact HeLa Cells
- Down regulation of poliovirus receptor RNA in HeLa cells resistant to poliovirus infection.
- Inhibition of Sindbis Virus Replication in HeLa Cells by Poliovirus
- Effect of Poliovirus on Deoxyribonucleic Acid Synthesis in HeLa Cells
