Relationship between gene co-expression and sharing of transcription factor binding sites in Drosophila melanogaster

AUTOR(ES)

Marco, Antonio

FONTE

Oxford University Press

RESUMO

Motivation: In functional genomics, it is frequently useful to correlate expression levels of genes to identify transcription factor binding sites (TFBS) via the presence of common sequence motifs. The underlying assumption is that co-expressed genes are more likely to contain shared TFBS and, thus, TFBS can be identified computationally. Indeed, gene pairs with a very high expression correlation show a significant excess of shared binding sites in yeast. We have tested this assumption in a more complex organism, Drosophila melanogaster, by using experimentally determined TFBS and microarray expression data. We have also examined the reverse relationship between the expression correlation and the extent of TFBS sharing.

Documentos Relacionados

• Relationship between gene co-expression and probe localization on microarray slides
• Quantifying the relationship between co-expression, co-regulation and gene function
• Co-expression of corticotropin-releasing factor and vasopressin immunoreactivity in parvocellular neurosecretory neurons of the adrenalectomized rat.
• Computational verification of protein-protein interactions by orthologous co-expression
• Inter-species differences of co-expression of neighboring genes in eukaryotic genomes