Relationship of gold and penicillamine therapy to diffuse interstitial lung disease.

AUTOR(ES)

Scott, D L

RESUMO

Seven cases of diffuse interstitial lung disease (DILD) are reported with an unequivocal temporal relationship between the development of the lung disease and treatment with gold (6 cases) and penicillamine (1 case). They were characterised clinically by the sudden onset of dyspnoea and crepitations and radiologically by diffuse bilateral pulmonary shadowing. Most showed evidence of hypersensitivity such as eosinophilia, a raised serum IgE level in response to gold, proteinuria, thrombocytopenia, or an immediate postinjection reaction. DILD is a serious complication of treatment with gold and penicillamine that is commoner than generally realised.

Documentos Relacionados

• Diffuse interstitial lung disease due to AA amyloidosis.
• Lipoprotein macroaggregates in bronchoalveolar lavage fluid from patients with diffuse interstitial lung disease.
• Value of Tru-cut lung biopsy in focal and diffuse lung disease.
• Lung function, breathing pattern, and gas exchange in interstitial lung disease.
• Focusing on diffuse (interstitial) lung disease: a rapidly evolving field