Relationships of interleukin-10 with the regulatory T cell ratio and prognosis of cervical cancer patients
AUTOR(ES)
Wang, Beibei, Wang, Haoyu, Li, Peiquan, Wang, Liangliang, Liu, Hongli, Liu, Jingbo, Wang, Lihua
FONTE
Clinics
DATA DE PUBLICAÇÃO
03/12/2018
RESUMO
OBJECTIVE: This study investigated serum interleukin-10 (IL-10) levels, changes in peripheral blood CD4+CD25+ regulatory T cell (PBCDT) ratios, and the prognosis of cervical cancer (CC) patients. METHODS: Seventy patients with CC composed the observation group, and 70 healthy subjects composed the control group. The PBCDT ratios in the CC patients and healthy subjects were calculated. Serum IL-10 levels were detected with a double antibody sandwich enzyme-linked immunosorbent assay (ELISA). RESULTS: The PBCDT ratio was higher in the patients with active CC [12.16±2.41%] than in the control subjects [6.34±1.05%]. Serum IL-10 levels were higher in the patients with CC [384±106 pg/ml] than in the control subjects [104±50 pg/ml]; the differences in both PBCDT ratio and IL-10 level were statistically significant (p<0.01). Serum IL-10 levels were positively correlated with PBCDT ratios (r=0.375, p<0.05). The 5-year patient survival rate was significantly higher in the low serum IL-10 group (64.2%) than in the high serum IL-10 group (42.8%, p=0.012). CONCLUSIONS: PBCDT ratios and serum IL-10 levels are related to CC activity. These factors are reciprocally related and influence one another, and both are involved in the development and progression of CC. Low IL-10 expression is beneficial regarding the survival of patients with CC.
Documentos Relacionados
- Interferon-gamma and interleukin-10 production by mononuclear cells from patients with advanced head and neck cancer
- Interleukin-10 inhibits apoptotic cell death in infectious mononucleosis T cells.
- Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.
- Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii.
- Regulatory Role of Interleukin-10 in Experimental Group B Streptococcal Arthritis