RELEASE OF NEWLY SYNTHESIZED DOPAMINE FROM DOPAMINE-CONTAINING TERMINALS IN THE STRIATUM OF THE RAT*

AUTOR(ES)

Besson, M. J.

RESUMO

The extraneuronal spontaneous efflux of 3H-dopamine synthesized endogenously in dopamine terminals has been demonstrated in vitro, by collecting the 3H amine in superfusates of isolated striatum of the rat previously incubated with 3H-tyrosine. The 3H-dopamine newly synthesized appears to be preferentially released. Furthermore, amphetamine and a monoamine oxidase inhibitor (Carton) markedly increased the release of 3H-dopamine. This effect was also observed with substances normally contained in some striatal neurons: acetylcholine and 5-hydroxytryptamine.

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