Renal mesangial cell cultures as a model for study of erythropoietin production.
AUTOR(ES)
Kurtz, A
RESUMO
Mesangial cells derived from isolated glomeruli of rat kidney were grown as homogeneous cell lines in culture. They released, into the culture medium, erythropoietin that had free terminal galactosyl residues and was therefore not active in vivo. The production of erythropoietin by these cells was significantly enhanced by either lowering the PO2 in the incubation atmosphere or by adding cobalt chloride to the culture medium. Therefore, mesangial cells in culture may be considered as an in vitro system in which the regulation of erythropoietin production can be studied under well-defined conditions.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=394189Documentos Relacionados
- Erythropoietin Production in Cultures of Goat Renal Glomeruli
- Differentiation in human amniotic fluid cell cultures: I: Collagen production.
- Continuous production of erythropoietin by an established human renal carcinoma cell line: development of the cell line.
- Development of the indusium griseum. III. An autoradiographic study of cell production.
- Interaction of nitric oxide and cyclic guanosine 3',5'-monophosphate in erythropoietin production.
