REPLICATION AND PROPERTIES OF DNA IN NICOTINAMIDE ADENINE DINUCLEOTIDE DEFICIENCY OF Escherichia coli CELLS
AUTOR(ES)
Nozawa, Ryushi
RESUMO
When niacin-requiring E. coli was starved of niacin, a precursor of nicotinamide adenine dinucleotide (NAD), the cells elongated and synthesis of DNA was inhibited while syntheses of RNA and protein continued. The cellular NAD concentration decreased to less than one tenth of the normal level in niacin deficiency, but no change in DNA ligase level was detected. The apparent inhibition of DNA synthesis can be explained as due to reduction in the activity of the cofactor, NAD, for the enzyme.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=223538Documentos Relacionados
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