Repression of the Overproduction of Porphyrin Precursors in Acute Intermittent Porphyria by Intravenous Infusions of Hematin
AUTOR(ES)
Bonkowsky, H. L.
RESUMO
In a patient with a severe attack of acute intermittent porphyria, hematin given intravenously caused marked diminution of serum δ-aminolevulinic acid and porphobilinogen. The decline of aminolevulinate was more rapid than that of porphobilinoge. After 2 days of hematin administration, about 5 days were required for δ-aminolevulinic acid, and 11 days for porphobilinogen to return to the concentrations that were detected before treatment. Urinary excretion of both compounds also decreased after hematin administration. Considerable amounts of porphobilinogen were also found in the cerebrospinal fluid of the patient.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=389510Documentos Relacionados
- Repression of the overproduction of porphyrin precursors in acute intermittent porphyria by intravenous infusions of hematin
- Repression by Hematin of Porphyrin Biosynthesis in Erythrocyte Precursors in Congenital Erythropoietic Porphyria
- ACUTE INTERMITTENT PORPHYRIA: THE FIRST “OVERPRODUCTION DISEASE” LOCALIZED TO A SPECIFIC ENZYME
- Autonomic neuropathy in acute intermittent porphyria.
- Acute intermittent porphyria studies with fibroblasts.
