Resistance of Pseudomonas aeruginosa to Imipenem Induced by Eluates from Siliconized Latex Urinary Catheters Is Related to Outer Membrane Protein Alterations
AUTOR(ES)
Martínez-Martínez, Luis
FONTE
American Society for Microbiology
RESUMO
The activity of imipenem against Pseudomonas aeruginosa HUS-3 decreased by 16 times in the presence of substances eluted from siliconized latex urinary catheters (SLUCs). SLUCs did not inactivate imipenem or increase β-lactamase activity. The outer membrane of P. aeruginosa HUS-3 grown in the presence of eluate lacked an OprD-like protein and expressed a new 50-kDa protein. The decreased activity of imipenem against P. aeruginosa in the presence of SLUCs is related to the loss of an OprD-like protein and the expression of a new outer membrane protein.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=89088Documentos Relacionados
- Zinc Eluted from Siliconized Latex Urinary Catheters Decreases OprD Expression, Causing Carbapenem Resistance in Pseudomonas aeruginosa
- Imipenem resistance in Pseudomonas aeruginosa resulting from diminished expression of an outer membrane protein.
- Selective imipenem resistance in Pseudomonas aeruginosa associated with diminished outer membrane permeability.
- Alterations in outer membrane proteins of Pseudomonas aeruginosa associated with selective resistance to quinolones.
- Imipenem-induced resistance to antipseudomonal beta-lactams in Pseudomonas aeruginosa.