Restriction fragment length polymorphism of the human c-fms gene.
AUTOR(ES)
Xu, D Q
RESUMO
By using blot hybridization with a v-fms probe, a polymorphism for EcoRI, HindIII, and BamHI restriction endonuclease sites associated with the human c-fms locus was observed in a random adult population. This restriction fragment length polymorphism can be explained on the basis of the existence of two alleles, a and b, and is due to a short (congruent to 500 base pairs) deletion characteristic of allele a. The distribution in the analyzed population (48 unrelated individuals) is 23% heterozygotes ab, 75% homozygotes bb, and 2% homozygotes aa. Though the inheritance of this polymorphism follows a Mendelian pattern, the children from couples ab X bb are of the following genotype: 74% ab and 26% bb. These deviations from the expected frequencies of 50% suggest a selective pressure in favor of heterozygotes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=397666Documentos Relacionados
- Isolation of new oncogenic forms of the murine c-fms gene.
- Chromosomal localization of the human c-fms oncogene.
- Reassessment of the murine c-fms proto-oncogene sequence.
- Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.
- Dinucleotide repeat polymorphism at the human c-fms proto-oncogene for the CFS-1 receptor (CFS1R)