Retraction of the Drosophila germ band requires cell–matrix interaction
AUTOR(ES)
Schöck, Frieder
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
Integrins and laminins are important mediators of cell–matrix interactions in both vertebrates and invertebrates. Here, we show that germ-band retraction in the Drosophila embryo, during which the tail end of the embryo retracts to its final posterior position, allows the investigation of cell spreading and lamellipodia formation in real time in vivo. We demonstrate that α1, 2 laminin and αPS3βPS integrin are required for the spreading of a small group of cells of the amnioserosa epithelium over the tail end of the germ band. We further implicate a role for this spreading in the process of germ-band retraction.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=196012Documentos Relacionados
- Cell-Matrix Adhesions Differentially Regulate Fascin Phosphorylation
- Characterization of Cell–Matrix Adhesion Requirements for the Formation of Fascin Microspikes
- Fibronectin Polymerization Regulates the Composition and Stability of Extracellular Matrix Fibrils and Cell-Matrix Adhesions
- Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions
- Basal Extracellular Signal-Regulated Kinase Activity Modulates Cell-Cell and Cell-Matrix Interactions