Role of Adrenal Cortical Function in Toxicity of Polyriboinosinic·Polyribocytidylic Acid and Its Component Homopolymers
AUTOR(ES)
Zedeck, Morris S.
RESUMO
Adrenalectomized rats are 1000 times more sensitive to lethal effects of the double-stranded complex polyriboinosinic·polyribocytidylic acid than intact rats. They are protected from such lethal effects by corticosterone. The complex can rapidly induce diffuse, severe necrosis of villous epithelium in small intestine without damage in crypts. Injection of the individual homopolymers, polyriboinosinic acid and polyribocytidylic acid, separately but in rapid succession is at least as lethal as injection of the complex.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283185Documentos Relacionados
- Increased Susceptibility of Cells Treated with Interferon to the Toxicity of Polyriboinosinic·Polyribocytidylic Acid
- Modified polyriboinosinic-polyribocytidylic acid complex: modulation of toxicity for rabbits by alterations in components.
- Modified polyriboinosinic-polyribocytidylic acid complex: sustained interferonemia and its physiological associates in humans.
- Modified polyriboinosinic-polyribocytidylic acid, an immunological adjuvant.
- Topical polyriboinosinic-polyribocytidylic acid complex in the treatment of recurrent genital herpes.