Role of Cell-Mediated Immunity in the Recovery of Cattle from Primary and Recurrent Infections with Infectious Bovine Rhinotracheitis Virus
AUTOR(ES)
Davies, D. H.
RESUMO
When cattle infected with infectious bovine rhinotracheitis virus (IBRV) were treated 3 months later with a synthetic corticosteroid, consistent recrudescence of the infection was observed. Suppression of cell-mediated immunity, as measured by lymphocyte transformation responses, could be demonstrated at the time of recrudescence. Treatment with adrenocorticotropic hormone and trigeminal neurotomy also resulted in recrudescence of IBRV, but immunosuppression was not detected in these animals. The detection of specific, antigen-induced, lymphocyte transformation responses at the time of recovery from both primary and recurrent infections suggests that cell-mediated immunity may be important in determining the duration and severity of the recurrent infection. However, immunosuppression may not be the direct mechanism of recrudescence.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=422884Documentos Relacionados
- Vaccines and cell-mediated immunity.
- Depressed specific cell-mediated immunity to Herpes simplex virus type 1 in patients with recurrent herpes labialis.
- Respiratory Tract Cell-Mediated Immunity: Comparison of Primary and Secondary Response
- Immunity to pathogenic free-living amoebae: role of cell-mediated immunity.
- Suppression of cell-mediated immunity after infection with attenuated rubella virus.
