Role of Tumor Necrosis Factor Alpha in the Host Response of Mice to Bacteremia Caused by Pneumolysin-Deficient Streptococcus pneumoniae
AUTOR(ES)
Benton, Kimberly A.
FONTE
American Society for Microbiology
RESUMO
Pneumolysin-deficient mutant strains of Streptococcus pneumoniae are known to cause less-severe sepsis than wild-type pneumococcal strains that produce pneumolysin. This difference is associated with greater host resistance in mice infected with the pneumolysin-deficient strains. These studies show that the host resistance developed during the first 1 to 2 days after infection with a pneumolysin-deficient mutant strain is dependent on tumor necrosis factor alpha but is apparently independent of interleukin 1β (IL-1β) or IL-6. Survival beyond 5 days appeared to depend on the ability of the mice to produce IL-1β.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=107980Documentos Relacionados
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