Salmonella infection increases porcine antibacterial peptide concentrations in serum.
AUTOR(ES)
Zhang, G
RESUMO
PR-39 is a multifunctional neutrophil peptide involved in host defense and inflammation. To investigate the involvement of PR-39 in a Salmonella choleraesuis infection, a PR-39 enzyme immunoassay was developed. The concentrations of PR-39 in serum were 13.6 +/- 1.9 ng/ml before challenge and increased (P < 0.01) threefold by 10 to 14 days postinfection. Peripheral blood neutrophil counts paralleled the changes in the concentrations of PR-39 in serum, both returned to basal values by 4 weeks postinfection. These findings suggest that the concentrations of serum PR-39 reflect the involvement of this antibacterial peptide in the host's response to an S. choleraesuis infection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=170657Documentos Relacionados
- Sucralfate significantly reduces ciprofloxacin concentrations in serum.
- Strategies for control of zidovudine concentrations in serum.
- Comparison of ceftazidime concentrations in bile and serum.
- Impact of ciprofloxacin on theophylline clearance and steady-state concentrations in serum.
- Potentiation of antibacterial activity of azithromycin and other macrolides by normal human serum.