Salmonella typhimurium virulence in a burned-mouse model.
AUTOR(ES)
Carsiotis, M
RESUMO
Various features of salmonellosis were examined in a burned-mouse model. In this model, which uses an outbred mouse strain, a challenge dose of ca. 100 CFU with any of several strains of Salmonella typhimurium caused a fatal infection. A variety of mutated strains attenuated for virulence in Salmonella-susceptible parenterally infected mice were also attenuated in the burned-mouse model. When administered as live vaccines injected intraperitoneally the same attenuated strains provided between slight and complete protection against subsequent lethal challenge subcutaneously at the site of a burn. The correspondence of results obtained in the burned-mouse model with those seen in other mouse models coupled with the unique advantages of the burned-mouse model argue for the usefulness of the model in studies of salmonellosis and in testing of strains constructed for use as live vaccines.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=313536Documentos Relacionados
- Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model.
- Avirulence of a Pseudomonas aeruginosa algC mutant in a burned-mouse model of infection.
- Effects of antiinflammatory agents on chronic Salmonella typhimurium infection in a mouse model.
- Virulence of different Pseudomonas species in a burned mouse model: tissue colonization by Pseudomonas cepacia.
- Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model.
