Secondary absence of mitochondria in Giardia lamblia and Trichomonas vaginalis revealed by valyl-tRNA synthetase phylogeny
AUTOR(ES)
Hashimoto, Tetsuo
FONTE
The National Academy of Sciences
RESUMO
Nuclear-coded valyl-tRNA synthetase (ValRS) of eukaryotes is regarded of mitochondrial origin. Complete ValRS sequences obtained by us from two amitochondriate protists, the diplomonad, Giardia lamblia and the parabasalid, Trichomonas vaginalis were of the eukaryotic type, strongly suggesting an identical history of ValRS in all eukaryotes studied so far. The findings indicate that diplomonads are secondarily amitochondriate and give further evidence for such conclusion reached recently concerning parabasalids. Together with similar findings on other amitochondriate groups (microsporidia and entamoebids), this work provides critical support for the emerging notion that no representatives of the premitochondrial stage of eukaryotic phylogenesis exist among the species living today.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=22662Documentos Relacionados
- Valyl-tRNA synthetase modification-dependent restriction of bacteriophage T4.
- Transfer RNA determinants for translational editing by Escherichia coli valyl-tRNA synthetase
- A neutron investigation of yeast valyl-tRNA synthetase interaction with tRNAs.
- Nucleotide sequence of Escherichia coli valyl-tRNA synthetase gene valS.
- Structure and regulation of expression of the Bacillus subtilis valyl-tRNA synthetase gene.