Selective host range restriction of goat cells for recombinant murine leukemia virus and feline leukemia virus type A.
AUTOR(ES)
Fischinger, P J
RESUMO
We isolated a strain of normal goat fibroblasts which was uniquely selective in that it allowed the replication of xenotropic murine leukemia virus but not polytropic recombinant murine leukemia virus. In addition, feline leukemia virus type A replication was severely diminished in these goat cells, whereas feline leukemia virus type B and feline endogenous RD114-CCC viruses replicated efficiently. No other known cells exhibit this pattern of virus growth restriction. These goat cells allow the study of xenotropic murine leukemia virus in mixtures which also contain recombinant murine leukemia virus and may be helpful in eliminating feline leukemia virus type which often coexists in feline sarcoma or leukemia virus mixtures with other feline leukemia virus types.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=171336Documentos Relacionados
- A phenotypic host range alteration determines RD114 virus restriction in feline embryonic cells.
- Host restriction of Friend leukemia virus: gag proteins of host range variants.
- Tumorigenic Potential of a Recombinant Retrovirus Containing Sequences from Moloney Murine Leukemia Virus and Feline Leukemia Virus
- Fv-1 host restriction of Friend leukemia virus: oligonucleotide analysis of host range variants.
- Novel Host Range and Cytopathic Variant of Ecotropic Friend Murine Leukemia Virus
