Selective inhibition of gamma-glutamyl-cycle enzymes by substrate analogs.

AUTOR(ES)

Griffith, O W

RESUMO

Substrate analogs have been obtained that selectively inhibit the reactions of the gamma-glutamyl cycle or that are susceptible to only limited metabolism by the cycle. Thus, glutathione synthesis may be inhibited and analogs of glutathione may be synthesized that do not participate in transpeptidation. Specific inhibitors of gamma-glutamylcyclotransferase and 5-oxoprolinase have been obtained. The findings offer new approaches to the in vivo study of the cycle and also to the design of more specifically directed analogs of inhibitors such as methionine sulfoximine and 6-diazo-5-oxonorleucine.

Documentos Relacionados

• Evidence that the gamma-glutamyl cycle functions in vivo using intracellular glutathione: effects of amino acids and selective inhibition of enzymes.
• p-Cymene pathway in Pseudomonas putida: selective enrichment of defective mutants by using halogenated substrate analogs.
• Substrate recognition by Escherichia coli MutY using substrate analogs.
• Inhibition of sterol transmethylation by S-adenosylhomocysteine analogs.
• Inhibition of Plant Growth by 2-Mercaptobenzimidazole Analogs. 123