Selective Inhibitory Effect of Two 2-Nitronaphthofuran Derivatives on Growth and Induction of Transformation of Rous Sarcoma Virus-Infected Chicken Embryo Fibroblasts
AUTOR(ES)
Goldé, Alice
RESUMO
Two 2-nitronaphthofuran derivatives exhibited a dose-dependent lethal effect on Rous sarcoma virus-tranformed chicken embryo fibroblasts. When they were added at time of infection, they prevented cell transformation, but not virus replication, in a dose-dependent manner. Since the two derivatives inhibited mainly the DNA sythesis, we assume that they altered some early DNA-dependent cell event required for cell transformation and not for the integration of provirus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=186048Documentos Relacionados
- Effect of 5-methylcytidine on virus production in avian sarcoma virus-infected chicken embryo cells.
- Comparison of Rous Sarcoma Virus-Specific Deoxyribonucleic Acid Polymerases in Virions of Rous Sarcoma Virus and in Rous Sarcoma Virus-Infected Chicken Cells
- Transformation-dependent increases in endogenous cytochalasin-like activity in chicken embryo fibroblasts infected by Rous sarcoma virus.
- Loss of transformed phenotype upon senescence of Rous sarcoma virus-infected chicken neuroretinal cells.
- Roles of Calcium, Serum, Plasma, and Folic Acid in the Control of Proliferation of Normal and Rous Sarcoma Virus-Infected Chicken Fibroblasts
