Selective Membrane Toxicity of the Polyene Antibiotics: Studies on Natural Membranes
AUTOR(ES)
Hsuchen, Chuen-Chin
RESUMO
The effect of polyene antibiotics on Candida albicans, human erythrocytes, and Acholeplasma laidlawii was studied. The results sustain the observations made with lecithin-sterol liposomes. The distribution of double bonds in the membrane sterol nucleus appears to be of major importance in conferring polyene susceptibility; those sterols with the ergosterol nucleus are far more effective than those with a nucleus similar to cholesterol. Different polyenes vary in their membrane selectivity. The clinical implications of these observations are discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=444549Documentos Relacionados
- Selective Membrane Toxicity of the Polyene Antibiotics: Studies on Lecithin Membrane Models (Liposomes)
- PURITY STUDIES ON POLYPEPTIDE ANTIBIOTICS: BACITRACIN 1
- Modulation of macrophage tumoricidal capability by polyene antibiotics: support for membrane lipid as a regulatory determinant of macrophage function.
- NYSTATIN BINDING BY PROTOPLASTS AND A PARTICULATE FRACTION OF NEUROSPORA CRASSA, AND A BASIS FOR THE SELECTIVE TOXICITY OF POLYENE ANTIFUNGAL ANTIBIOTICS*
- Selective Filtration of Antibiotics Through Collodion Membranes