Sequence homologies among the three yolk polypeptide (Yp) genes in Drosophila melanogaster.
AUTOR(ES)
Yan, Y L
RESUMO
To identify candidates for cis-acting sequences that regulate the sex-, stage-, and cell-specific expression of three coordinately regulated yolk polypeptide genes (Yp) in Drosophila melanogaster, we have mapped the Yp3 transcript, sequenced a 4278 bp DNA fragment containing the Yp3 gene, compared Yp3 region sequences to corresponding parts of Yp1 and Yp2, and compared the predicted amino acid sequence of YP3 to YP1 and YP2. The results showed that the Yps are largely homologous in translated regions, especially in the 3' half of the genes. Untranscribed flanking regions had little homology. A conserved inverted repeat (the H-box) has homology both to vertebrate steroid hormone receptor binding sites and to the ecdysone control region of Drosophila's hsp23. These results identify sequences to mutate in order to define elements that regulate Yp gene expression and govern YP polypeptide function.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=340398Documentos Relacionados
- 20-Hydroxyecdysone stimulates the accumulation of translatable yolk polypeptide gene transcript in adult male Drosophila melanogaster.
- Structural analysis of the three vitellogenin genes in Drosophila melanogaster.
- Variability in the molecular organization of the 5S RNA genes among strains of Drosophila melanogaster.
- Sequence analysis of the complete cDNA and encoded polypeptide for the Glued gene of Drosophila melanogaster.
- Transfer RNA genes of Drosophila melanogaster.