Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor.
AUTOR(ES)
Takeda, J
RESUMO
Gastric inhibitory polypeptide (GIP) is a 42-amino acid hormone that stimulates insulin secretion in the presence of glucose. Complementary DNA clones encoding human GIP were isolated from a library prepared with RNA from duodenum. The predicted amino acid sequence indicates that GIP is derived by proteolytic processing of a 153-residue precursor, preproGIP. The GIP moiety is flanked by polypeptide segments of 51 and 60 amino acids at its NH2 and COOH termini, respectively. The former includes a signal peptide of about 21 residues and an NH2-terminal propeptide of 30 amino acids. GIP is released from the precursor by processing at single arginine residues. There is a region of nine amino acids in the COOH-terminal propeptide of the GIP precursor that has partial homology with a portion of chromogranin A as well as pancreastatin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=299217Documentos Relacionados
- Sequence of a cDNA encoding Syrian hamster islet amyloid polypeptide precursor.
- Cloning and sequence analysis of cDNA encoding urotensin I precursor.
- Cloning and sequence analysis of cDNA for human renin precursor.
- Cloning and sequence analysis of a cDNA encoding porcine mitochondrial aspartate aminotransferase precursor.
- Cloning and characterization of human liver cDNA encoding a protein S precursor.
