Seroconversion to virus-specific pre-early nuclear antigens in infants with primary cytomegalovirus infection.

AUTOR(ES)

Chiba, S

RESUMO

Antibodies to human cytomegalovirus (CMV)-specific antigens were determined in sera serially collected from 10 infants with primary CMV infection. Antibodies to pre-early nuclear antigens (PENA), which are detectable in human embryonic lung cells within 3 h of CMV infection by anticomplement immunofluorescence staining, developed in all the patients. However, in contrast to the early response of anti-early antigens (EA), anti-late antigens (LA), and immunoglobulin M antimembrane antigens (MA), seroconversion or the maximum antibody response to PENA was usually observed 1 or more months later. Immunoglobulin M antibody to MA became undetectable soon after recovery from illness, followed by a decrease in anti-EA, anti-PENA, and then anti-LA titers. Results indicated analogy of the clinical significance of anti-PENA in CMV infection to that of anti-Epstein-Barr nuclear antigen in infectious mononucleosis and support the idea that parallel determinations of anti-PENA and IgM anti-MA antibodies can be useful for identifying the acute or chronic phase of primary CMV infection.

Documentos Relacionados

• Detection of antibodies to pre-early nuclear antigen and immediate-early antigens in patients immunized with cytomegalovirus vaccine.
• Immunoglobulin G to virus-specific early antigens in congenital, primary, and reactivated human cytomegalovirus infections.
• Immunoglobulin G to Virus-Specific Early Antigens in Congenital, Primary, and Reactivated Human Cytomegalovirus Infections
• Human antibody response to herpes simplex virus-specific polypeptides after primary and recurrent infection.
• Development of virus-specific CD4+ T cells during primary cytomegalovirus infection