Shipment Impairs Lymphocyte Proliferative Responses to Microbial Antigens

AUTOR(ES)

Betensky, Rebecca A.

FONTE

American Society for Microbiology

RESUMO

Lymphocyte proliferation assays (LPAs) are widely used to assess T-lymphocyte function of patients with human immunodeficiency virus infection and other primary and secondary immunodeficiency disorders. Since these assays require expertise not readily available at all clinical sites, specimens may be shipped to central labs for testing. We conducted a large multicenter study to evaluate the effects of shipping on assay performance and found significant loss of LPA activity. This may lead to erroneous results for individual subjects and introduce bias into multicenter trials.

Documentos Relacionados

• Lymphocyte proliferative responses to human immunodeficiency virus antigens in vitro.
• Regulatory effect of monocytes on T cell proliferative responses to oral microbial antigens.
• Method for identifying microbial antigens that stimulate specific lymphocyte responses: application to Salmonella.
• beta-Endorphin enhances lymphocyte proliferative responses.
• Inhibition of lymphocyte proliferative responses by ribavirin.