Silver Sulfadiazine: Effect on the Growth and Metabolism of Bacteria
AUTOR(ES)
Rosenkranz, Herbert S.
RESUMO
Even though the addition of silver sulfadiazine (AgSu) to purified deoxyribonucleic acid (DNA) results in the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu. AgSu blocked macromolecular syntheses in treated bacteria, DNA synthesis being slightly more sensitive to this inhibitory action. The ribosomes, ribonucleic acid, and DNA isolated from treated cells were normal qualitatively. Bacteria deficient in DNA polymerase were not more sensitive than their parent strain to the lethal action of AgSu. Radioactive AgSu was localized mainly in the cytoplasmic membrane fraction of treated cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=444322Documentos Relacionados
- Silver Sulfadiazine: Effect on the Ultrastructure of Pseudomonas aeruginosa
- Silver Sulfadiazine: In Vitro Antibacterial Activity
- Silver Sulfadiazine: Interaction with Isolated Deoxyribonucleic Acid
- Impact of chlorhexidine-silver sulfadiazine-impregnated central venous catheters on in vitro quantitation of catheter-associated bacteria.
- Impact of chlorhexidine-silver sulfadiazine-impregnated central venous catheters on in vitro quantitation of catheter-associated bacteria.