Simple, mild, and highly efficient synthesis of 2-substituted benzimidazoles and bis-benzimidazoles

AUTOR(ES)

Eren, Bilge, Bekdemir, Yunus

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2014

RESUMO

A new convenient method for preparation of 2-substituted benzimidazoles and bis-benzimidazoles is presented. In this method, o-phenylenediamines were condensed with bisulfite adducts of various aldehydes and di-aldehydes under neat conditions by microwave heating. The results were also compared with results of synthesis by conventional heating under reflux. Structures of the products were confirmed by infrared, ¹H- and 13C-NMR spectroscopy. Short reaction times, good yields, easy purification of products, and mild reaction conditions are the main advantages of this method.

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