SMX-1 virus-induced inhibition of ecotropic and recombinant proviral sequence amplification in thymuses of AKR mice.
AUTOR(ES)
Buchhagen, D L
RESUMO
SMX-1 virus delays the appearance of spontaneous thymomas in AKR mice which have been inoculated as young adults by the intrathymic route. Analyses of high-molecular-weight thymus DNAs from SMX-1 virus-inoculated AKR mice indicated the absence of 3' recombinant proviral-cellular DNA junction fragments generated by EcoRI and PvuII digestion. An average of five recombinant proviral fragments were detected in DNAs from spontaneous thymomas that developed in medium-injected control mice. Preleukemic mice that amplify murine leukemia virus-related antigens on their thymocyte surface contained unintegrated proviruses in their thymus DNAs, and 2.3-kilobase EcoRI and 2.1-kilobase PvuII recombinant DNA fragments were detected.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254566Documentos Relacionados
- Lack of AKR ecotropic provirus amplification in AKR leukemic thymuses.
- Deregulation of the c-myc oncogene in virus-induced thymic lymphomas of AKR/J mice.
- Free and integrated recombinant murine leukemia virus DNAs appear in preleukemic thymuses of AKR/J mice.
- Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice.
- Immunomodulation of encephalomyocarditis virus-induced disease in A/J mice.
