Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation
AUTOR(ES)
Filipp, Dominik
FONTE
The National Academy of Sciences
RESUMO
Induction of resting B cell growth and differentiation requires a complex series of temporally coordinated signals that are initiated on contact with activated helper T cells. These signals complement one another, each rendering the B cell susceptible to factors supporting progressive activation. Here, we demonstrate that soluble CD14 (sCD14) bypasses the physiological sequelae of events that limit B cell activation. B cell growth and differentiation in vitro is induced by both native and recombinant forms of sCD14 at nanomolar concentrations. sCD14-mediated cellular activation does not require membrane CD14 expression, depends on a region of CD14 that is not involved in lipopolysaccharide binding, and requires functional Toll-like receptor 4. Consistent with biological activity of sCD14 in vitro, its administration to neonatal mice enhances Ig secretion. The results presented establish sCD14 as a naturally occurring soluble B cell mitogen of mammalian origin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=14634Documentos Relacionados
- Endotoxin-Mediated Endothelial Cell Injury and Activation: Role of Soluble CD14
- Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line.
- CD14 Is Expressed and Released as Soluble CD14 by Human Intestinal Epithelial Cells In Vitro: Lipopolysaccharide Activation of Epithelial Cells Revisited
- Soluble CD14 Activates Monocytic Cells Independently of Lipopolysaccharide
- Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids.