Somatic action potentials are sufficient for late-phase LTP-related cell signaling

AUTOR(ES)

Dudek, Serena M.

FONTE

The National Academy of Sciences

RESUMO

A question of critical importance confronting neuroscientists today is how biochemical signals initiated at a synapse are conveyed to the nucleus. This problem is particularly relevant to the generation of the late phases of long-term potentiation (LTP). Here we provide evidence that some signaling pathways previously associated with late-LTP can be activated in hippocampal CA1 neurons without synaptic activity; somatic action potentials, induced by backfiring the cells, were found to be sufficient for phosphorylation of extracellular signal-regulated kinase-1/2 and cAMP response element-binding protein, as well as for induction of zif268. Furthermore, such antidromic stimulation was adequate to rescue “tagged” synapses (early-LTP) from decay. These results show that a synapse-to-nucleus signal is not necessary for late-phase LTP-associated signaling cascades in the regulation of gene expression.

Documentos Relacionados

• Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration.
• Requirement for Uracil-DNA Glycosylase during the Transition to Late-Phase Cytomegalovirus DNA Replication
• Late-phase expression of a murine cytomegalovirus immediate-early antigen recognized by cytolytic T lymphocytes.
• Quantitative Analysis of T-Cell Receptor β Variable-Gene Usage in Cutaneous Late-Phase Reactions: Implications for T-Lymphocyte Recruitment in Cutaneous Inflammation
• Comparison of Inflammatory Events during Developing Immunoglobulin E-Mediated Late-Phase Reactions and Delayed-Hypersensitivity Reactions