Species specificity of attachment and damage to oviduct mucosa by Neisseria gonorrhoeae.
AUTOR(ES)
Johnson, A P
RESUMO
Neisseria gonorrhoeae colony type 1 were inoculated into organ cultures of oviducts obtained from various animal species. Gonococci rapidly attached to extensive areas of the mucosa of human oviducts (fallopian tubes), entered the mucous-secreting cells, and caused histological damage to the tissues. In addition, 2 to 4 days after infection there was complete loss of ciliary activity. In contrast, gonococci attached very scantily or not at all to the mucosa of rabbit, porcine, or bovine oviducts. However, the organisms multiplied in the medium of these organ cultures and were located sometimes in the base of mucosal cells and in large numbers in the submucosa. Despit this, there was no histological evidence of damage, and at least 7 days after infection ciliary activity was maintained equally as well as it was in uninfected control cultures. The host specificity of N. gonorrhoeae appears to be determined, at least in part, by a markedly diminished ability of the organisms to attach to and damage the genital mucosa of nonhuman species.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=421309Documentos Relacionados
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