Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression
AUTOR(ES)
Li, Jiwen
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
Specific recruitment of corepressor complexes containing histone deacetylases (HDAC) by transcription factors is believed to play an essential role in transcriptional repression. Recent studies indicate that repression by unliganded nuclear hormone receptors and by the Mad family of repressors requires distinct HDAC-containing corepressor complexes. In this work, we show that unliganded TR specifically recruits only the closely related N-CoR and SMRT–HDAC3 complexes, whereas the Mad1 recruits only the Sin3–HDAC1/2 complex. Significantly, both the Sin3 and Mi-2/NURD complexes also exhibit constitutive association with chromatin and contribute to chromatin deacetylation in a nontargeted fashion. These results suggest that HDAC complexes can contribute to gene repression by two distinct mechanisms as follows: (1) specific targeting by repressors and (2) constitutive association with chromatin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=155360Documentos Relacionados
- Targeting of N-CoR and histone deacetylase 3 by the oncoprotein v-ErbA yields a chromatin infrastructure-dependent transcriptional repression pathway
- Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene
- Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo
- Transcriptional Repression by Blimp-1 (PRDI-BF1) Involves Recruitment of Histone Deacetylase
- A role for histone deacetylase activity in HDAC1-mediated transcriptional repression
