Statistical characterization of nucleic acid sequence functional domains.
AUTOR(ES)
Smith, T F
RESUMO
It has long been recognized that various genome classes were distinguishable on the basis of base composition and nearest neighbor frequencies. In addition Grantham et al. (8) have recently presented evidence that these distinctions are preserved at the level of codon usage. As discussed in this report it is now clear that these and related statistics can uniquely characterize the various functional domains of the genome. In particular peptide coding, intervening segments, structural RNA coding and mitochondrial domains of the vertebrate genome are uniquely characterizable. The statistical measures not only reflect understood functional differences among these domains but suggest others. The ability of these simple statistics of nucleic acid sequences to reflect so much of the encoded complex pattern information and/or effects of selective constraints is somewhat surprising. Here, we investigated the statistical measures most distinctive of the various domains and then linked them to our current understandings in so far as possible.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=325873Documentos Relacionados
- The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains.
- Nucleic acid binding and intracellular localization of unr, a protein with five cold shock domains.
- Analysis of the herpes simplex virus type 1 OriS sequence: mapping of functional domains.
- Sequence conservation in the Saccharomyces and Kluveromyces GAL11 transcription activators suggests functional domains.
- Poly(A) polymerase contains multiple functional domains.