Step of Dichlorvos Inhibition in the Pathway of Aflatoxin Biosynthesis

AUTOR(ES)

Yao, Raymond C.

RESUMO

Dichlorvos (dimethyl 2,2-dichlorovinyl phosphate) inhibits the biosynthesis of aflatoxin by Aspergillus parasiticus. Cultures treated with dichlorvos excrete an orange pigment which can be converted into aflatoxin B1 by the untreated mycelia. The orange pigment was partially identified as an acetyl derivative of versiconol-type compound. In the presence of dichlorvos, sterigmatocystin is converted into aflatoxin B1 without being interfered, but averufin is converted into the orange pigment instead of aflatoxin B1. Therefore, dichlorvos appears to block an enzymatic step in the aflatoxin biosynthetic pathway, which lies beyond averufin but before sterigmatocystin, at the formation of the orange pigment.

Documentos Relacionados

• Inhibition of Aflatoxin Production and Tentative Identification of an Aflatoxin Intermediate „Versiconal Acetate” from Treatment with Dichlorvos
• Clustered Pathway Genes in Aflatoxin Biosynthesis
• Inhibition of aflatoxin biosynthesis by tolnaftate.
• The potential effects of Zataria multiflora Boiss essential oil on growth, aflatoxin production and transcription of aflatoxin biosynthesis pathway genes of toxigenic Aspergillus parasiticus
• Enzymatic formation of the bisfuran structure in aflatoxin biosynthesis.