STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg

AUTOR(ES)

Giachini, F.R., Lima, V.V., Hannan, J.L., Carneiro, F.S., Webb, R.C., Tostes, R.C.

FONTE

Brazilian Journal of Medical and Biological Research

DATA DE PUBLICAÇÃO

2011-11

RESUMO

Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.

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