Stimulation of Antibacterial Vaccination in Mice by Polyadenylic Acid: Polyuridylic Acid Complex

AUTOR(ES)
RESUMO

The effect of polyadenylic acid:polyuridylic acid complex (poly A:U) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant or in saline. Addition of 300 μg of poly A:U to vaccines rendered 3 × 108B. melitensis cells in saline as immunogenic as 3 × 1011 cells in oil adjuvant against a severe B. abortus challenge. In the mouse and Brucella system, poly A:U exerts an adjuvant effect on immunity but does not stimulate production of circulating antibodies that could be demonstrated at the time of autopsy.

ACESSO AO ARTIGO

Documentos Relacionados