STIMULATION OF C14-MELATONIN SYNTHESIS FROM C14-TRYPTOPHAN BY NORADRENALINE IN RAT PINEAL IN ORGAN CULTURE*
AUTOR(ES)
Axelrod, Julius
RESUMO
Previous work has shown that the activity of the melatonin-forming enzyme in the rat pineal gland is elevated in rats kept in continuous darkness as compared to those kept in continuous light. Information about environmental lighting reaches the pineal gland via nerves that liberate noradrenaline. Rat pineal glands in organ culture can form C14-melatonin from C14-tryptophan as follows: tryptophan → 5-hydroxytryptophan → serotonin → melatonin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=277838Documentos Relacionados
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